Updated: Saturday, 04 Apr 2015 16:13 | Comments
Uxizandre was the notable absentee after 17 entries were revealed for the Melling Chase at Aintree on Friday.
A setback suffered after Cheltenham means the Ryanair Chase winner will not run again this season.
The Alan King-trained seven-year-old brought the house down last month when making all for a famous success in the hands of Tony McCoy - a final Festival winner for the soon-to-retire champion.
Frank Berry, racing manager to owner JP McManus, said: "He had a setback after Cheltenham, so he won't be running in Liverpool and he's finished for the season.
"Hopefully we will have him back for the autumn."
Sire De Grugy is the star turn in the Grade One event as he could step up to two and a half miles for the first time.
The former Champion Chase hero was fourth in this year's renewal of the Cheltenham feature after an interrupted campaign and will have a new jockey following the broken leg suffered by regular pilot Jamie Moore.
Moore's brother Josh will take over on the nine-year-old, trained by his father, Gary.
Leading the opposition is the Colin Tizzard-trained Cue Card, who will be having his first run since finishing fifth in the King George at Kempton on Boxing Day.
Nicky Richards' Simply Ned was one place behind Sire De Grugy at Cheltenham and tries again, while God's Own, who gave Un De Sceaux a fright in the Arkle, and Al Ferof also look players.
Gordon Elliott's Ryanair third Don Cossack spearheads the Irish challenge together with Willie Mullins' Champagne Fever.
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